Transparency is essential to trust and efficiency in research. In light of SARS-CoV-2 and COVID-19, there has been increasing discussion about the importance of past and evolving research related to the virus and disease. Ensuring researchers have access to past data and findings that may provide insights is urgent and important, and fortunately is getting some attention with efforts like LitCovid, an open-resource literature hub for COVID scholarship. Despite this encouraging development, it is important that we don’t lose sight of the importance of research transparency in reinforcing the goals of efficiency, efficacy, and long-term trust in biomedical research.